abstract：:Nitric oxide is a small potentially toxic molecule and a diatomic free radical. We report the interaction of L-arginine, oxygen and calcium with the synthesis of nitric oxide in heart mitochondria. Nitric oxide synthesis is increased in broken rat heart mitochondria compared with intact and permeabilized mitochondria....

journal_title：Amino acids

authors： Saavedra-Molina A,Ramírez-Emiliano J,Clemente-Guerrero M,Pérez-Vázquez V,Aguilera-Aguirre L,González-Hernández JC

更新日期：2003-01-01 00:00:00

abstract：:Reaction between glutathione and ribose was carried out to study the volatiles formed via Maillard reaction and their antioxidant activity as well as their role in inhibition of LDL oxidation. The simultaneous distillation-extraction technique was used for trapping the volatile components followed by GC-MS analysis. T...

journal_title：Amino acids

authors： El-massry K,Farouk A,El-Ghorab A

更新日期：2003-01-01 00:00:00

abstract：:N-[(Z)-N-Benzoyl- or N-boc-(2-fluorophenyl)dehydroalanyl]-(R)- or (S)-phenyl-alanines 1,2,5 and 6 were hydrogenated in the presence of chiral and achiral rhodium complexes. The optical induction is compared to the results obtained using the corresponding esters as substrates. ...

journal_title：Amino acids

authors： Döbler C,Kreuzfeld HJ,Fischer C,Michalik M

更新日期：2002-06-01 00:00:00

abstract：:Green tea which is widely consumed in China, Japan and India, contains polyphenolic compounds, which account for 30% of the dry weight of the leaves. Most of the polyphenols are flavanols, of which (-)-epigallocatechin-3-gallate (EGCG) is most abundant. Epidemiological studies revealed that the incidences of stomach a...

journal_title：Amino acids

authors： Bachrach U,Wang YC

更新日期：2002-01-01 00:00:00

abstract：:Until now information about the influence of puberty on gingival tissue responses to Ni-Ti alloy haven't been available. Since our previous researches have demonstrated that Ni-Ti appliances have an influence on hyperplastic gingivopathy and data has pointed out a possible hormonal influence on the susceptibility of g...

journal_title：Amino acids

authors： Venza M,Visalli M,Ruggeri P,Cicciù D,Teti D

更新日期：2002-01-01 00:00:00

abstract：:Taurine chloramine (TauCl), a product of neutrophil myeloperoxidase - halide system, formed by a reaction of taurine with HOCl, is known as an anti-microbial and anti-inflammatory long-lived oxidant. We previously reported that TauCl inhibits in vitro the production of proinflammatory cytokines (IL-6, IL-8) by RA syno...

journal_title：Amino acids

authors： Kwaśny-Krochin B,Bobek M,Kontny E,Gluszko P,Biedroń R,Chain BM,Maśliński W,Marcinkiewicz J

更新日期：2002-01-01 00:00:00

abstract：:Glucosinolates are amino acid-derived natural plant products found throughout the Capparales order. Glucosinolates and their degradation products have a wide range of biological activities, e.g. in plant defense as deterrents against insect and fungi. The conversion of amino acids to aldoximes is a key step in glucosi...

journal_title：Amino acids

authors： Mikkelsen MD,Petersen BL,Olsen CE,Halkier BA

更新日期：2002-01-01 00:00:00

abstract：:The article traces the development of research on the naturally occurring amino acid L-3,4-dihydroxyphenylalanine (L-dopa), from the first synthesis of its D,L racemate in 1911, and the isolation of its L-isomer from seedling of Vicia faba beans to the amino acid's successful application, from 1961 onward, as the most...

journal_title：Amino acids

authors： Hornykiewicz O

更新日期：2002-01-01 00:00:00

abstract：:On a biochemical level, conventional antidepressants have been shown to modulate synaptic levels of biogenic amines (i.e., serotonin, norepinephrine, and dopamine), most often by interfering with reuptake processes or inhibiting metabolism. Strategies directed at modulating glutamatergic transmission may overcome the ...

journal_title：Amino acids

authors： Skolnick P

更新日期：2002-01-01 00:00:00

abstract：:Using the olfactory bulbectomy model of depression, we examined the antidepressant-like activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Bulbectomized rats required a significantly greater number of trials to acquire the response similar to sham-operated controls in the passive avoidance model. Both the...

journal_title：Amino acids

authors： Wieronska JM,Szewczyk B,Branski P,Palucha A,Pilc A

更新日期：2002-01-01 00:00:00

abstract：:Ocular ischemia resulting from perfusion disturbances may play a major role in initiation of glaucoma. Possibly secondary to ischemia autoimmunogenic events are activated in glaucoma patients with increased prevalence of systemic autoimmune diseases. The determination of potential molecular markers in blood leukocytes...

journal_title：Amino acids

authors： Golubnitschaja O,Wunderlich K,Decker C,Mönkemann H,Schild HH,Flammer J

更新日期：2002-01-01 00:00:00

abstract：:The relationship between taurine concentrations of plasma, whole blood, serum and skeletal muscle during taurine depletion and repletion was investigated in cats, to identify the most useful indicators of taurine status. Sixteen cats were fed a purified diet containing either 0 or 0.15 g/kg taurine for 5 months. Treat...

journal_title：Amino acids

authors： Pacioretty L,Hickman MA,Morris JG,Rogers QR

更新日期：2001-12-01 00:00:00

abstract：:The effects of Red Bull Energy Drink, which includes taurine, glucuronolactone, and caffeine amongst the ingredients, were examined over 3 studies in a total of 36 volunteers. Assessments included psychomotor performance (reaction time, concentration, memory), subjective alertness and physical endurance. When compared...

journal_title：Amino acids

authors： Alford C,Cox H,Wescott R

更新日期：2001-01-01 00:00:00

abstract：:When a V3 sequence obtained on the n-th year after infection with human immunodeficiency virus type 1 (HIV-1) was supposed to change into a V3 sequence on the n + 1-th year, the variation between the above two sequences was analyzed by means of entropic chaos degree. The entropic chaos degree measures chaotic aspects ...

journal_title：Amino acids

authors： Sato K,Ohya M

更新日期：2001-01-01 00:00:00

abstract：:In 3T3 cells temperatures higher than physiological stimulated amino acid transport activity in a dose-dependent manner up to 44 degrees C. However, the temperature increase did not induce widespread transport increase of all other nutrients tested. The activities of both amino acid transport systems A and ASC were en...

journal_title：Amino acids

authors： Petronini PG,Caccamo AE,Alfieri RR,Bonelli MA,Borghetti AF

更新日期：2001-01-01 00:00:00

abstract：:Neurofilaments (NFs) are integral constituents of the neuron playing a major role in brain development, maintenance, regeneration and the pattern of expression for NFs suggests their contribution to plasticity of the neuronal cytoskeleton and creating and maintaining neuronal architecture. Using immune-histochemical t...

journal_title：Amino acids

authors： Bajo M,Yoo BC,Cairns N,Gratzer M,Lubec G

更新日期：2001-01-01 00:00:00

abstract：:Glutamine is the most abundant amino acid in the body. It is an important fuel for some key cells of the immune system. Both the plasma concentration of glutamine and the functional ability of immune cells in the blood are decreased after prolonged, exhaustive exercise. Glutamine feeding has had beneficial effects in ...

journal_title：Amino acids

authors： Castell LM,Newsholme EA

更新日期：2001-01-01 00:00:00

abstract：:Glutaryl-CoA dehydrogenase deficiency (GDD), which is one of the most frequent organic acid disorders, is characterized by a specific age- and regional-dependent neuropathology. We hypothesized that the distinct brain damage in GDD could be caused by the main pathologic metabolites, the organic acids glutaric (GA) and...

journal_title：Amino acids

authors： Kölker S,Ahlemeyer B,Krieglstein J,Hoffmann GF

更新日期：2000-01-01 00:00:00

abstract：:The cellular amino acid composition of plant cells was analyzed. The callus of carrot (Daucus carota), leaves of Torenia fournieri and protocomb-like body of Cymbidium, s.p. were examined as examples of plant cells. The cellular amino acid compositions differed in the plant cells, but their basic patterns were quite s...

journal_title：Amino acids

authors： Sorimachi K,Okayasu T,Akimoto K,Niwa A

更新日期：2000-01-01 00:00:00

abstract：:The isolated single organotypic slice model allows to investigate the effects of drugs and toxins on the expression of transcription factors in the striatum without dopaminergic and glutamatergic interactions. In this study the effects of margatoxin and iberiotoxin on the expression of c-fos mRNA by in situ hybridizat...

journal_title：Amino acids

authors： Saria A,Fischer HS,Humpel C,Pfattner A,Schatz DS,Schuligoi R

更新日期：2000-01-01 00:00:00

abstract：:The effects of metabotropic glutamate receptor (mGluR) activation were studied in medium spiny neurons and large aspiny (LA) interneurons by means of electrophysiological and optical recordings. DCG-IV and L-SOP, agonists for group II and III mGluRs, respectively, produced a presynaptic inhibitory effect on corticostr...

journal_title：Amino acids

authors： Pisani A,Bernardi G,Bonsi P,Centonze D,Giacomini P,Calabresi P

更新日期：2000-01-01 00:00:00

abstract：:The ventral pallidum is part of the corticoaccumbo-thalamocortical loop of the basal ganglia. In the past the function of this structure was discussed as a pure relay station in the process of limbic-motor integration. Some recent studies, however, underline that on the level of the ventral pallidum motor behavior can...

journal_title：Amino acids

authors： Kretschmer BD

更新日期：2000-01-01 00:00:00

abstract：:In this review, recent studies on the electrophysiological effects of de novo synthesized ("endogenous") kynurenic acid (KYNA) are discussed. Endogenous KYNA is normally formed as a byproduct of tryptophan metabolism. Evidence for a physiological role in neuronal excitability has not been strong, in part because brain...

journal_title：Amino acids

authors： Scharfman HE,Goodman JH,Schwarcz R

更新日期：2000-01-01 00:00:00

abstract：:Taurine and glutamate were monitored by microdialysis technique during various cerebral insults: a. Application of K+ triggered a cortical spreading depression (CSD). Taurine and glutamate increased concomitantly but recovery of glutamate was faster than that of taurine. b. Application of NMDA induced also CSD but onl...

journal_title：Amino acids

authors： Scheller D,Szathmary S,Kolb J,Tegtmeier F

更新日期：2000-01-01 00:00:00

abstract：:Hepatocytes were cultured for 3 days as spheroids (aggregates) or as monolayers in basal medium and in sulfur amino acid-supplemented media. Cultured hepatocytes had low levels of cysteine dioxygenase (CDO) activity and normal levels of gamma-glutamylcysteine synthetase (GCS) and cysteine-sulfinate decarboxylase (CSDC...

journal_title：Amino acids

authors： Ohta J,Kwon YH,Stipanuk MH

更新日期：2000-01-01 00:00:00

abstract：:The influence of nitric oxide synthase (NOS) activity on the KCl-evoked amino acid concentrations was investigated by in vivo microdialysis in the striatum in a rat model of excitotoxic lesion. Basal microdialysate levels of amino acids decreased during the quinolinic acid-induced neurodegeneration process, except for...

journal_title：Amino acids

authors： Böckelmann R,Reiser M,Horn TF,Wolf G

更新日期：2000-01-01 00:00:00

abstract：:Nitric oxide synthase (NOS) activities are responsible for the enzymatic conversion of L-arginine into NO and L-citrulline. Relatively low amounts of NO are produced in intestinal epithelial cells or are released from nerve endings. The effects of NO production are related to the maintenance of epithelial integrity an...

journal_title：Amino acids

authors： Guihot G,Guimbaud R,Bertrand V,Narcy-Lambare B,Couturier D,Duée PH,Chaussade S,Blachier F

更新日期：2000-01-01 00:00:00

abstract：:Spore coat-associated alanine racemase of Bacillus subtilis, which converts L-alanine to D-alanine, that is, the germinant to the competitive inhibitor, to regulate spore germination for survival of the organism under unfavorable growth conditions, was examined. The dormant spores, L-alanine-initiated germination of w...

journal_title：Amino acids

authors： Kanda-Nambu K,Yasuda Y,Tochikubo K

更新日期：2000-01-01 00:00:00

abstract：:Glycyl-L-proline (gly-pro) is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins. We postulated a relationship between defective gly-pro hydrolysis, increased collagen degradation and skin destruction. T...

journal_title：Amino acids

authors： Le J,Perier C,Peyroche S,Rascle F,Blanchon MA,Gonthier R,Frey J,Chamson A

更新日期：1999-01-01 00:00:00

abstract：:Some of the chemistry of amino acids going on in our laboratory (Laboratoire des Amino acides Peptides et Protéines) is described as well as some mass spectrometry methodology for their characterization particularly on solid supports. Several aspects are presented including: (i) the stereoselective synthesis of natura...

journal_title：Amino acids

authors： Bouifraden S,Drouot C,el Hadrami M,Guenoun F,Lecointe L,Mai N,Paris M,Pothion C,Sadoune M,Sauvagnat B,Amblard M,Aubagnac JL,Calmes M,Chevallet P,Daunis J,Enjalbal C,Fehrentz JA,Lamaty F,Lavergne JP,Lazaro R,Rollan

更新日期：1999-01-01 00:00:00

abstract：:Protooncogenes (PO) play a crucial role for brain biology and pathology. Only the concerted action of protooncogenes enables normal brain development. The reliable and sensitive quantification of brain PO is still holding centre stage in neurobiological research. The aim of our study was therefore the determination of...

journal_title：Amino acids

authors： Schatzmann-Turhani D,Greber-Platzer S,Cairns N,Lubec G

更新日期：1999-01-01 00:00:00

abstract：:Thrombin, the most potent physiological platelet agonist interacts with cells through a specific G protein-coupled receptor which has been cloned and sequenced. Synthetic thrombin receptor peptides (TRAPs) comprising the first 5 amino acids (SFLLR and SFLLR-NH2) of the new N-terminus tethered ligand of the thrombin re...

journal_title：Amino acids

authors： Alexopoulos K,Matsoukas J,Tselios T,Roumelioti P,Mavromoustakos T,Holada K

更新日期：1998-01-01 00:00:00

abstract：:Taurine is known to increase ATP-dependent calcium ion (Ca2+) uptake in retinal membrane preparations and in isolated rod outer segments (ROS) under low calcium conditions (10 microM) (Pasantes-Morales and Ordóñez, 1982; Lombardini, 1991). In this report, ATP-dependent Ca2+ uptake in retinal membrane preparations was ...

journal_title：Amino acids

authors： Militante JD,Lombardini JB

更新日期：1998-01-01 00:00:00

abstract：:The purpose of the present study was to investigate the relationship between plasma carnitine concentration and body composition variation in relation to muscular and fat masses since there is no experimentally proved correlation between plasma carnitine and body masses. We used bioelectric impedance analysis (BIA), t...

journal_title：Amino acids

authors： Gatti R,De Palo CB,Spinella P,De Palo EF

更新日期：1998-01-01 00:00:00

abstract：:The regulation of the expression of indoleamine 2,3-dioxygenase (IDO) was studied in cloned murine macrophages (MT2) and microglial (N11) cells. Both cell lines express IDO and inducible nitric oxide synthase activity after interferon-gamma (IFN-gamma) stimulation. The regulation of IDO expression appears to differ in...

journal_title：Amino acids

authors： Alberati-Giani D,Cesura AM

更新日期：1998-01-01 00:00:00

abstract：:Dopa and related catecholamines and their degradation products have been demonstrated to have neurotoxic potential in a number of cellular and in vivo experiments. Several mechanisms have been hypothesized to be involved including generation of prooxidant products that subsequently oxidize membrane lipids and exposed ...

journal_title：Amino acids

authors： VonVoigtlander PF,Fici GJ,Althaus JS

更新日期：1998-01-01 00:00:00

abstract：:Blood-borne angiotensin II (AngII) is known to mediate water-intake by its excitatory effect on neurons in the subfornical organ (SFO). Conversely, nitric oxide (NO) has exclusively inhibitory effects on rat SFO-neurons and on SFO-mediated water-intake. Extracellular and patch-clamp recordings from freshly dissociated...

journal_title：Amino acids

authors： Schmid HA

更新日期：1998-01-01 00:00:00

abstract：:This study examines the hypothesis that glutamate tonically suppresses the activity of the enzyme aromatic L-amino acid decarboxylase (AADC), and hence the biosynthesis of dopamine, to explain how antagonists of glutamate receptors might potentiale the motor actions of L-DOPA in animal models of Parkinson's disease. A...

journal_title：Amino acids

authors： Fisher A,Biggs CS,Starr MS

更新日期：1998-01-01 00:00:00

abstract：:Hypotaurine, concentrated under reduced pressure in HCl solution, partially (30-40%) degrades into taurine (about 30%), 2-aminoethyl-2-aminoethanethiolsulfonate (about 10%) and ethanolamine. The degradation products were identified using LC/APCI-MS, NMR, amino acid analysis and various chromatographies. The identities...

journal_title：Amino acids

authors： Duprè S,Spirito A,Pinnen F,Sugahara K,Kodama H

更新日期：1998-01-01 00:00:00

abstract：:A subline growing in medium without arginine and ornithine was established from a rat Reuber hepatoma cell line (R-Y121B·cho). The subline designated R-Y117B·cho was able to grow in glutamine, arginine and ornithine-free, glutamate-supplemented medium. Arginine synthesis from glutamate requires four urea cycle enzymes...

journal_title：Amino acids

authors： Yamamoto K,Niwa A

更新日期：1996-09-01 00:00:00